tal
I am reading that the 2018 bike will take tires up to 32c.  Is anyone riding this bike with 650 wheels?  With what tire width?  I would think this would be a good option for turning the Synapse into a gravel bike.  Comments?
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chas
All depends on if the chain stays are flared...
Be careful lowering that Bottom Bracket too much.
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sgtrobo
My wife has a 2018 Cannondale Synapse, the tires on it now are just shy of 700x35c (Roubaix Pro on SLX24 rims, tubeless)

I'd be comfortable putting UCI cyclocross tires on it.  If you're lighter weight, you could definitely use it as primarily a road bike with secondary use as gravel.  

I definitely wouldn't use it with 650b though, the BB is already pretty low, and width is where the issue is with tire clearance, so wider tires won't be the answer.  
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tal
Thanks for the response.  The Cannondale site says max tire width is 32c but apparently that is conservative.  My intent is to use the Synapse primarily as an endurance road bike with limited gravel duty.  If the Synapse can indeed take a tire close to 35c I'll be satisfied.
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